To achieve an adequate and safe weight loss in the elderly, the goal should be to reduce the dose of the drug. The objective of this study was to compare the safety and tolerability of baclofen 20 mg/d in elderly patients with diabetes mellitus (DM). The protocol was designed and developed as a randomized, double-blind, placebo-controlled, crossover study with a 3-month washout period. After the first week, participants underwent the following three tests: (a) determination of the body weight; (b) determination of fasting glucose, cholesterol, blood pressure, and insulin; (c) determination of the fasting insulin response; and (d) the change of body weight. The patients were also instructed to report their diabetes symptoms and their response to lifestyle changes. The study protocol was approved by the Medical Ethics Committee of the National University of Istanbul. All participants signed the informed consent.
This was a 3-month, double-blind, randomized, crossover study with a 3-month washout period, which was performed at the National University Hospital of Istanbul (NUI). We used the validated data system (SPSS Inc., Chicago, IL, USA) for the study. After the first week, all participants underwent a blood sample measurement of fasting glucose, lipid profile (triglycerides) and blood pressure. A total of 200 diabetic patients, who were aged between 18 and 55 years, were included in the study. All the participants underwent a fasting blood glucose of 5 mg/dL, cholesterol of 160 mg/dL and blood pressure of 100/50 mmHg. The patients also underwent a lipid profile, including triglycerides, LDL-C, HDL-C, total-SQ-5 and free-lemmatins. The patients received a dose of 20 mg/d baclofen at a fixed dose of 10 mg/d for 3 weeks. The dose of baclofen 20 mg/d was adjusted according to body weight and the changes in body weight were calculated. After the 3-month washout period, all participants underwent an evaluation of their body weight and blood glucose, lipid profile and blood pressure and an oral glucose tolerance test. At the end of the washout period, blood was collected into EDTA tubes and stored at −70 °C. Blood samples were analyzed for creatinine, total-SQ-5, FSH, estradiol, total-FSH, estradiol/HDL-C, free-lemmatins, SHBG and total-FSH. The study was approved by the Ethics Committee of the National University of Istanbul (No. 16-15.12.2015). All participants gave written informed consent to participate in the study.
The mean age of the study population was 63.7 years (range 24–86 years) and the average BMI was 28.8 kg/m2 (range 18.6–42.8 kg/m2). The main clinical features and laboratory parameters in all patients are shown in Table. All patients with diabetes mellitus had a BMI of 25 or more and had an estimated glomerular filtration rate of 5 mL/min/1.73m2 (range 1.6–8.3 mL/min/1.73m2). The most common side effects of the drug were nausea (20.2%), diarrhea (15.6%), vomiting (11.4%), and abdominal pain (10.5%). No severe adverse events were observed in the study group. The mean baseline and follow-up periods were 4.5 months (5–6.9) and 2.6 months (2–3.9) respectively.
Table 1. Clinical characteristicsThe average body weight, fasting blood glucose and cholesterol, and blood pressure were significantly different in the patients treated with baclofen 20 mg/d (p <0.001). A significant difference was noted in the blood pressure when compared with the placebo group (p <0.001). No significant difference was noted in the fasting insulin response between the baclofen 20 mg/d and placebo groups (p = 0.9). At the end of the study, there was a significant improvement in the fasting insulin response as compared to the placebo group (p <0.001). The mean change in total-FSH was significantly higher in the baclofen 20 mg/d group than the placebo group (p <0.001). There was no significant difference in the mean change in total-FSH between the baclofen 20 mg/d and placebo groups (p=0.89). The mean baseline and follow-up periods were 4.5 and 2.6 months respectively.
Table 2.If you have a mental health issue, including a diagnosis of PTSD, you should know the risks and benefits involved. The U. S. Food and Drug Administration (FDA) has classified BACLOFEN (benzodiazepine-clonazepam) as a controlled substance.
BACLOFEN is approved to treat symptoms of PTSD and the symptoms of other conditions that cause PTSD such as generalized anxiety disorder, post-traumatic stress disorder, and attention deficit disorder. It is also effective in treating some forms of post-traumatic stress disorder.
BACLOFEN is used to treat the symptoms of PTSD in adults and children. It is not approved to treat children younger than 12 years old.
The drug works by increasing the amount of GABA in the brain, which reduces the activity of other neurotransmitters.
This GABAergic system can help restore your mood and reduce the symptoms of depression and anxiety. BACLOFEN is also approved to help control your thoughts and feelings.
Like any other medication, BACLOFEN may cause side effects, although not everyone will experience them. Tell your doctor if any of these:
Tell your doctor about any side effects you experience. These may include:
Tell your doctor if you have or have had any of the following medical conditions:
If you experience any of the following symptoms, tell your doctor:
The FDA has approved BACLOFEN to treat PTSD and other conditions such as:
Tell your doctor about any other medications, supplements, or dietary changes you may be taking.
Like all medications, BACLOFEN may cause side effects, but not everyone will experience them.
Product Details:
| Minimum Order Quantity | 10 Strip |
| Brand | Baclofen |
| Form | Tablet |
| Packaging Size | 10*10 Tablets |
| Manufacturer | Alfa |
| Composition |
Baclofen Tablets is a muscle relaxant, that reduces muscle spasms, tension and stiffness in people with spasticity of multiple body parts (e.g. legs, arms, neck, shoulders, elbows, knees, and feet). Baclofen Tablets is used to treat multiple conditions of muscle and joint such as spasms and stiffness.
Baclofen Tablets works by blocking the action of gamma-aminobutyric acid (GABA) in the muscle cells of the spinal cord (cord and joint) by modulating the nerve action. GABA is a neurotransmitter that stimulates the activity of the central nervous system (CNS). Baclofen Tablets inhibits the action of GABA in the muscle cells of the spinal cord (cord and joint), which reduces the muscle spasms and stiffness.
Baclofen Tablets can make your muscles more tense and stiffer, which can make them more uncomfortable and painful. If you are in the process of taking the tablet, it is essential to follow the dosage and usage instructions provided by your healthcare provider.
It is recommended to consult your doctor before taking Baclofen Tablets to ensure safety and efficacy.
Before you begin taking Baclofen Tablets, inform your doctor about any ongoing medication, allergies, or medical conditions you may have, especially if you have liver, kidney or heart problems.
Some of the symptoms of a reaction with Baclofen Tablets may include difficulty in breathing, swelling of the face, lips, tongue or throat, and skin rash, hives, itching, and shortness of breath.
It is crucial to have an open communication with your doctor about all the medications, supplements, and herbal products you are taking. It is also important to inform your doctor of all the medications you are taking and inform them about any allergies you may have.
It is also crucial to inform your doctor of all the medicines you are using, including herbal medicines, vitamins, and herbal products.
Baclofen Tablets is used to treat muscle spasms, stiffness in muscles and painful conditions.
Baclofen Tablets can cause side effects, which are similar to other medications. Side effects may vary depending on the underlying cause of your muscle or joint pain. You may notice muscle pain, tenderness or stiffness when you first start taking Baclofen Tablets or have muscle spasms.
Common side effects of Baclofen Tablets may include muscle cramps, tenderness, and weakness. It is important to be aware of the possible side effects and inform your doctor about them. Baclofen Tablets can cause side effects in some people, such as muscle pain, joint stiffness, or numbness, tingling, and weakness.
Baclofen is used to treat a number of muscle spasms that occur due to certain conditions. The muscle spasms may be severe, persistent, or temporary. The most common muscle spasms include:
This condition can cause symptoms including:
Your doctor may advise you to take baclofen exactly as prescribed by your doctor. This is because baclofen may cause side effects such as muscle pain, weakness, dizziness, and drowsiness. If you do take baclofen and have any of these side effects, be sure to talk to your doctor about them.
It is not possible to determine the exact dose of baclofen you should take, but your doctor will determine the appropriate dosage for you based on your condition and how severe it is. If you are taking baclofen and you take baclofen as directed by your doctor, your doctor will take into account your age, weight, medical conditions, and other factors to decide what dose of baclofen you should take.
It is not possible to determine the exact dosage of baclofen you should take, but your doctor will determine the appropriate dosage for you based on your condition and how severe it is.
The baclofen you should take should not be taken in conjunction with alcohol or other sedatives. Alcohol is a depressant that causes muscle spasms. Drinking alcohol and other sedatives with baclofen may cause drowsiness, dizziness, and other side effects. You should avoid drinking alcohol while you are taking baclofen, as it can increase the risk of drowsiness and dizziness. Drinking alcohol and other sedatives together is not recommended unless prescribed by your doctor.
Baclofen is a medication used to treat muscle spasticity caused by spinal cord injuries, cerebral palsy, and other conditions. It is sold under the brand names Lioresal or Lioresal. Lioresal is also used to treat a muscle spasm caused by multiple sclerosis, cerebral palsy, or spinal cord diseases. Baclofen can also be used to treat muscle spasms caused by other conditions, such as multiple sclerosis, spinal cord diseases, or spinal cord injuries. Baclofen works by relaxing muscles and muscles in the spinal cord and spinal cord, which reduces muscle spasms and prevents pain.
The active ingredients of Baclofen are Lidocaine and Lioresal. It belongs to a class of drugs called muscle relaxants.
When a person is depressed, their body is unable to produce enough gamma-aminobutyric acid (GABA) to cause muscle spasms. GABA is a neurotransmitter that is released in the brain when certain chemicals in the brain are interrupted. GABA is a chemical that is normally produced in the nervous system in the spinal cord. When GABA is released, it can cause muscle spasms. By blocking its production of GABA, Baclofen helps to prevent muscle spasms and prevent painful muscle contractions.
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